The goal of his project is to create a compendium of genomic information to be mined for the development of new therapeutics. For this purpose, he and Dr. Steven Gullans have developed an assay for cell death in neuroblastoma cells in tissue culture. As the source of oxidative damage, they have formulated a 96-well assay system utilizing hydrogen peroxide as the oxidative and toxic agent. As a means to determining which genes are involved in conferring cell survival under neurotoxic conditions, Dr. Sarang is expanding his work from cell culture to animal models for Parkinson's Disease and ALS.