|
Dr. Satinder Sarang is a postdoctoral researcher
with our lab at the Center for Neurological Diseases (CND) and Lab
of Drug Discovery in Neurodegeneration (LDDN). He brings to our
group his expertise in pharmacology, toxicology, biochemistry and
enzymatic assay development. Prior to joining our group, he worked
on identifying glycine and GABA A receptor subunits and calcium
uptake and calpain activation.
His research focus is on molecular and pharmacological
mechanism of neuroprotection. The goal of his project is to create
a compendium of genomic information to be mined for the development
of new therapeutics. For this purpose, he and Dr. Steven Gullans
have developed an assay for cell death in neuroblastoma cells in
tissue culture. As the source of oxidative damage, they have formulated
a 96-well assay system utilizing hydrogen peroxide as the oxidative
and toxic agent. As a means to determining which genes are involved
in conferring cell survival under neurotoxic conditions, Dr. Sarang
is expanding his work from cell culture to animal models for Parkinson's
Disease and ALS.
Dr. Sarang is joined by Rudolphe Cadet and Andrew
Valeras who have been invaluable in their technical support in maintaining
cell cultures and carrying out an innumerable number of high throughput
assays to titrate and determine the degree of oxidative injury and
drug-induced recovery.
|
